“Pins and needles gone! I've tried B vitamins by themselves and a few different nerve supplements over the years without much success. Sense8 feels different. After about a week, the pins-and-needles sensation in my toes are gone. I appreciate that it's a balanced formula instead of just loading up on one ingredient. Using product for 2 months now and still making a difference.”
Verified Customer
DID YOU NOTICE?
A customer once asked why our label doesn't list fillers.
Because there aren't any.
Every ingredient in every capsule has a purpose.
Sense8: Physician-Formulated Support for Healthy Nerves
Sense8: Physician-Formulated Support for Healthy Nerves
Tingling. Burning. Numbness. Pins and needles. Sometimes it feels like an electrical shock. Hard to ignore, wherever it strikes.
Maybe it's your feet. Maybe it's your hands. Maybe it's another part of your body entirely. Your nerves run throughout your body, so these sensations aren't necessarily limited to your feet and hands.
You may not know exactly why it's happening. You just want it to stop.
Sense8 was built for exactly that moment.
Key Benefits
Sense8 was designed to help you:
- Enjoy your day with less tingling, burning, numbness and pins and needles.
- Get up, walk and move more comfortably with less nerve discomfort.
- Use your hands every day with less numbness, tingling or soreness.
- Sleep more comfortably with less burning, tingling or electric-shock sensations.
- Walk, shop, travel and enjoy your hobbies more comfortably.
- Give your nerves better nutritional support to help soothe nerve discomfort.
Your nervous system is complex. We don't believe supporting something that complex should begin and end with one or two popular nerve ingredients.
A formula can contain multiple ingredients and still be built primarily around one or two familiar nerve ingredients. Sense8 was intentionally built differently. Our doctors brought eight ingredients together as a team to support four different areas of nerve health.
Nerve Communication: Your nerves need to send signals clearly.
Nerve Structure: Nerves depend on healthy structures to support and protect those signals.
Nerve Environment: The environment around nerve pathways can affect how well they function.
Nerve Protection: Antioxidant defenses help protect nerve cells from everyday oxidative stress.
That's what makes the Sense8 approach different. Eight ingredients with different roles, working together to provide broader nutritional support for healthy nerve function.
Couldn't load pickup availability
In stock
Frequently Asked Questions
Sense8 is a physician-formulated supplement designed to support healthy nerve function, sensory comfort, and mental clarity. It addresses the nutritional, circulatory, and cellular factors that nerves depend on to communicate, repair, and maintain balance over time.
Think of your nerves like electrical wires. Each nerve is protected by a coating that acts like insulation. When that protective layer is under stress from nutrient deficiency, inflammation, or poor circulation, signals can misfire and produce sensations like tingling, numbness, or burning. Sense8 supports nerve communication, that protective insulation, cellular energy within nerve tissue, and the antioxidant and inflammatory balance nerves depend on.
Sense8 is designed to support healthy nerve signaling and sensation, reduce tingling and numbness associated with peripheral neuropathy, improve mental clarity and focus, and maintain the circulatory health that nerves depend on for oxygen and nutrients.
Sense8 was formulated for people experiencing tingling, numbness, burning, or discomfort in the hands or feet, those managing diabetes-related nerve concerns, people dealing with persistent brain fog or mental fatigue, and anyone looking to proactively support long-term nerve health.
Sense8 contains a physician-selected blend including R-alpha lipoic acid, methylcobalamin (B12), pyridoxine B6, P5P, benfotiamine, L-methylfolate, acetyl-L-carnitine, NAC, PEA (palmitoylethanolamide), and Lion's Mane. Each ingredient is chosen to support nerve repair, myelin integrity, cellular energy, and inflammatory balance at a dose grounded in clinical research.
Tingling and numbness most commonly result from peripheral neuropathy, which is nerve dysfunction driven by diabetes, nutrient deficiencies, poor circulation, accumulated physical stress, or chronic inflammation. These factors often accumulate gradually, which is why the symptoms can develop slowly and feel hard to pinpoint. Sense8 addresses the most correctable of these underlying factors through targeted nutritional support.
B6 and B12 are essential for producing myelin, the protective insulation that allows nerves to conduct signals efficiently. Deficiency in either is one of the most common and reversible causes of neuropathy symptoms. Sense8 uses methylcobalamin and P5P, the active forms of B12 and B6, which the body can use directly without conversion.
R-alpha lipoic acid is one of the most extensively studied nutrients for neuropathy support. It is a powerful antioxidant that reduces oxidative stress in nerve tissue, supports energy production within nerve cells, and has been shown in clinical research to improve neuropathy symptoms, particularly in people with diabetes.
PEA, or palmitoylethanolamide, is a naturally occurring compound the body produces in response to pain and inflammation. As a supplement it supports the body's own pain-modulating and anti-inflammatory processes, particularly in nerve tissue. It is especially valuable for people with chronic nerve discomfort because it works through a different pathway than most anti-inflammatory nutrients.
Most nerve supplements offer B vitamins and little else. Sense8 combines active-form B vitamins with R-alpha lipoic acid, acetyl-L-carnitine, benfotiamine, PEA, NAC, and Lion's Mane to address nerve health from multiple angles simultaneously: repair, structural protection, energy production, and inflammation. It is a coordinated system, not a single-nutrient product.
Yes. Inflammation creates pressure around nerves, irritates nerve pathways, and disrupts signal transmission. This can start a cycle where nerve stress triggers inflammation, inflammation amplifies discomfort, and discomfort contributes to more stress. Addressing inflammatory balance is one of the core mechanisms through which Sense8 supports nerve comfort.
Yes. Nerves have high metabolic demands and depend on consistent blood flow for oxygen and nutrients. Poor circulation is one of the leading contributors to peripheral neuropathy, particularly in people with diabetes or cardiovascular concerns. This is why improving circulation is a meaningful part of comprehensive nerve support.
Yes. Chronic stress elevates cortisol, promotes inflammation, disrupts blood sugar regulation, and impairs the repair processes that nerves depend on. Daily lifestyle factors including long periods of standing, sitting, repetitive movement, poor sleep, and dehydration accumulate over time and affect how nerves function and recover.
Yes. Peripheral nerves play a key role in proprioception, the body's sense of its own position and movement. When nerve function is impaired, balance and coordination can suffer. Supporting nerve health with Sense8 can contribute to improved stability over time with consistent use.
Yes. Several ingredients in Sense8 support microcirculation, the small-vessel blood flow that is most important for nerve tissue health. This makes Sense8 particularly valuable for people whose neuropathy is partly driven by circulatory insufficiency.
Some people experience early improvement within the first one to two weeks. Because nerve repair is a gradual process, most people see the most meaningful and consistent results after four to six weeks of daily use. Consistency is what drives the most significant outcomes.
Yes. Sense8 is designed for ongoing daily use. Nerve repair and maintenance are long-term processes, and consistent supplementation produces compounding benefits over time, particularly for people managing chronic neuropathy.
Yes. Sense8 pairs well with Pulse8 for comprehensive circulation support and Heal8+ for inflammation. For people managing diabetic neuropathy or significant nerve discomfort, combining all three provides a coordinated whole-system approach.
If you take prescription medications, particularly for diabetes, blood pressure, or neurological conditions, consult your healthcare provider before starting Sense8 or any dietary supplement.
We offer a 60-day money-back guarantee. If you are not satisfied for any reason, contact us for a full refund.
Think of your nerves like electrical wires running throughout your body.
Each one sends signals between your brain and everything else. Your feet. Your hands. Your organs. Your muscles. Like any electrical wire, those nerves depend on protective insulation to send clear, consistent signals. When that insulation becomes irritated, weakened, or stressed, the signals can misfire. The result is the tingling, burning, numbness, and pins and needles that bring so many people to their doctors with the same question: why does this keep happening?
The answer is rarely simple. And that is exactly why single-ingredient solutions rarely work.
Nerves do not fail for one reason. They fail when multiple systems stop supporting them at the same time. Cellular energy drops. Daily stress accumulates inside the cells nerves depend on. Inflammation puts pressure on nerve pathways. Nutritional gaps leave the protective insulation without what it needs to maintain itself. Each factor on its own might be manageable. Together they create a cycle that compounds over time.
Sense8 was designed to interrupt that cycle by supporting the four systems nerves depend on most.
Nerve Communication
Nerves send signals. When those signals become inconsistent, distorted, or interrupted, you feel it as tingling, numbness, or the unsettling sensation that something is not working the way it should. Methylcobalamin, the active form of Vitamin B12, supports healthy nerve signaling and the neurological function that consistent communication depends on. Benfotiamine, a fat-soluble form of Vitamin B1, provides additional support for the metabolic processes that keep nerve communication running efficiently.
Nerve Structure
The protective insulation around your nerves is not self-sustaining. It requires specific nutrients to maintain its integrity over time. Without them, the insulation weakens and the signals it is supposed to protect become vulnerable to distortion. R-Alpha Lipoic Acid supports the metabolic environment that nerve structure depends on. CoQ10 supports the cellular energy production that nerve cells require to maintain and repair themselves.
Nerve Environment
Even well-nourished nerves struggle when the environment around them is under stress. Inflammation puts pressure on nerve pathways, irritates surrounding tissue, and disrupts the signal transmission that normal sensation depends on. PEA, Palmitoylethanolamide, supports a balanced inflammatory response around nerve pathways, helping reduce the environmental stress that contributes to discomfort over time. Ashwagandha supports the body's broader stress response, helping maintain the neurological balance that nerve health depends on.
Nerve Protection
Nerves face constant oxidative stress from daily life. Without adequate antioxidant support, that stress accumulates and contributes to the cellular damage that affects how nerves function over time. Glutathione, one of the body's most powerful antioxidants, supports cellular protection and recovery at the nerve level. Lion's Mane mushroom has been studied for its potential role in supporting nerve growth factor activity and long-term neurological wellness.
Eight ingredients. Four systems. One goal.
Sense8 was not built around one ingredient or one mechanism. It was built around the understanding that nerve health requires coordinated support across multiple systems simultaneously. Each ingredient was selected for a specific role in that system, and for how it works alongside the others.
The tingling, burning, and numbness you have been living with may not be something you simply have to accept. Your nerves are telling you something. Sense8 was built to answer.
Ingredients per serving:
- Pure Methylcobalamin (Vitamin B12) — 300mcg (12,500% DV)
- Benfotiamine (Vitamin B1) — 100mg (8333% DV)
- Glutathione — 100mg
- Ashwagandha — 100mg
- Palmitoylethanolamide (PEA) — 50mg
- CoQ10 — 50mg
- R-Alpha Lipoic Acid — 300mg
- Lion's Mane — 50mg
Why we include each ingredient:
Methylcobalamin (Vitamin B12) — The active form of vitamin B12, supports healthy nerve signaling and the neurological function that consistent nerve communication depends on.
Benfotiamine (Vitamin B1) — A fat-soluble form of vitamin B1 that supports the metabolic processes that keep nerve communication running efficiently.
R-Alpha Lipoic Acid — Supports the metabolic environment that healthy nerve structure depends on.
CoQ10 — Supports the cellular energy production that nerve cells require to maintain and repair themselves.
Palmitoylethanolamide (PEA) — Supports a balanced inflammatory response around nerve pathways, helping reduce the environmental stress that contributes to discomfort over time.
Ashwagandha — Supports the body's broader stress response, helping maintain the neurological balance that nerve health depends on.
Glutathione — One of the body's most powerful antioxidants, supports cellular protection and recovery at the nerve level.
Lion's Mane — Studied for its potential role in supporting nerve growth factor activity and long-term neurological wellness.
Take 1-2 capsules daily. Many prefer 1 in the morning and 1 in the evening. For best results, use consistently over time.
THE RESEARCH BEHIND SENSE8
Sense8 combines eight ingredients selected to support nerve communication, nerve structure, the environment around nerve pathways, and cellular protection against oxidative stress. Below is some of the human research behind the ingredients.
Methylcobalamin (Vitamin B12) — 300mcg
Studied in a 2020 systematic review and meta-analysis of 15 randomized controlled trials in patients with diabetic or herpetic peripheral neuropathy. Mecobalamin alone was found to be more effective than active controls for clinical therapeutic efficacy. Most of the positive trials used injectable forms of methylcobalamin rather than oral capsules.
Benfotiamine (Vitamin B1) — 100mg
Studied in two randomized, placebo-controlled trials for diabetic polyneuropathy. A three-week pilot study (BEDIP) found improvement in neuropathy symptom scores. A larger six-week trial (BENDIP) in 165 patients found significant improvement in neuropathy symptom scores at doses of 300mg and 600mg per day. Both trials used doses of 300mg per day or higher, higher than the amount in Sense8.
R-Alpha Lipoic Acid — 300mg
Studied in a 2012 meta-analysis of 15 randomized controlled trials examining nerve conduction velocity and neuropathic symptoms, and in a 2023 dose-response meta-analysis evaluating oral doses of 600, 1200, and 1800mg per day. Most studied oral doses were 600mg or higher, double the amount in Sense8.
View 2023 dose-response meta-analysis →
CoQ10 — 50mg
Studied in a randomized, placebo-controlled trial in patients with diabetic polyneuropathy using 400mg per day for 12 weeks. The trial found significant improvement in neuropathy symptom scores, neuropathy impairment scores, and nerve conduction velocity. A separate randomized, placebo-controlled trial using 200mg per day for 12 weeks found improved total antioxidant capacity and reduced C-reactive protein in patients with diabetic neuropathy. Both studied doses were higher than the amount in Sense8.
Palmitoylethanolamide (PEA) — 50mg
Studied in a randomized, placebo-controlled trial in patients with diabetic-related peripheral neuropathic pain using 600mg per day for 8 weeks. The trial found reductions in pain, inflammatory markers, and sleep disturbance. The studied dose was substantially higher than the amount in Sense8.
Ashwagandha — 100mg
Studied in randomized, placebo-controlled trials examining stress, cortisol, and anxiety, and in a 2025 systematic review and meta-analysis of 15 randomized controlled trials. This research supports Ashwagandha's role in the body's broader stress response rather than as direct evidence of peripheral nerve effects. Most studied doses ranged from 240mg to 600mg per day, higher than the amount in Sense8.
Glutathione — 100mg
Studied in a randomized trial in elderly patients with type 2 diabetes using 500mg per day for 6 months, which found improved antioxidant status, reduced oxidative DNA damage, and improved HbA1c. This trial evaluated general antioxidant and metabolic outcomes in diabetic patients, not nerve-specific outcomes. The studied dose was higher than the amount in Sense8.
Lion's Mane — 50mg
Human clinical research on Lion's Mane has focused on cognitive function and mood, not peripheral nerve regeneration. A 2009 double-blind trial found improved cognitive scores in older adults with mild cognitive impairment after 16 weeks of supplementation, and a 2023 pilot study found improved processing speed and reduced subjective stress in younger adults. Lion's Mane's potential role in supporting nerve growth factor activity and peripheral nerve repair is based on animal and cell research; it has not been demonstrated in human peripheral nerve studies.
Full References
- Sawangjit R, Thongphui S, Chaichompu W, Phumart P. Efficacy and Safety of Mecobalamin on Peripheral Neuropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Alternative and Complementary Medicine. 2020;26(12):1117-1129.
- Haupt E, Ledermann H, Kopcke W. Benfotiamine in the treatment of diabetic polyneuropathy: a three-week randomized, controlled pilot study (BEDIP study). International Journal of Clinical Pharmacology and Therapeutics. 2005;43(2):71-77.
- Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Experimental and Clinical Endocrinology & Diabetes. 2008;116(10):600-605.
- Mijnhout GS, Kollen BJ, Alkhalaf A, Kleefstra N, Bilo HJG. Alpha Lipoic Acid for Symptomatic Peripheral Neuropathy in Patients with Diabetes: A Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology. 2012;2012:456279.
- Effects of Oral Alpha-Lipoic Acid Treatment on Diabetic Polyneuropathy: A Meta-Analysis and Systematic Review. Nutrients. 2023;15(16):3634.
- Hernandez-Ojeda J, Cardona-Munoz EG, Roman-Pintos LM, Troyo-Sanroman R, Ortiz-Lazareno PC, Cardenas-Meza MA, Pascoe-Gonzalez S, Miranda-Diaz AG. The effect of ubiquinone in diabetic polyneuropathy: a randomized double-blind placebo-controlled study. Journal of Diabetes and its Complications. 2012;26(4):352-358.
- Fakhrabadi MA, Ghotrom AZ, Mozaffari-Khosravi H, Hadi Nodoushan H, Nadjarzadeh A. Effect of Coenzyme Q10 on Oxidative Stress, Glycemic Control and Inflammation in Diabetic Neuropathy: A Double Blind Randomized Clinical Trial. International Journal for Vitamin and Nutrition Research. 2014;84(5-6):252-260.
- Pickering E, Steels EL, Steadman KJ, Rao A, Vitetta L. A randomized controlled trial assessing the safety and efficacy of palmitoylethanolamide for treating diabetic-related peripheral neuropathic pain. Inflammopharmacology. 2022;30(6):2063-2077.
- Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019;98(37):e17186.
- Bachour G, Samir A, Haddad S, Houssaini MA, El Radad M. Effects of Ashwagandha Supplements on Cortisol, Stress, and Anxiety Levels in Adults: A Systematic Review and Meta-Analysis. BJPsych Open. 2025;11(Suppl S1):S39.
- Kalamkar S, Acharya J, Kolappurath Madathil A, et al. Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients. Antioxidants (Basel). 2022;11(5):1026.
- Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research. 2009;23(3):367-372.
- Docherty S, Doughty FL, Smith EF. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023;15(22):4842.
More Support For Your Health and Wellness
-
Sleep8: Wake up feeling like you actually slept.
Regular price $42.99 USDRegular price$42.99 USDSale price $42.99 USD -
Active8 MAX Natural Anti-Inflammatory Support for Joint Comfort & Mobility
Regular price $42.99 USDRegular price -
Pulse8: Circulation & Cardiovascular Support
Regular price $42.99 USDRegular price -
Heal8+: Advanced Tissue Repair & Recovery
Regular price $79.99 USDRegular price
Real answers to the health questions your doctor rarely has time to answer — written by a physician who believes you deserve to understand what's happening inside your own body.
More on Sense8
Explore the Wellness Blog
Why Some People Need Caffeine at 10 AM, 2 PM, a...
If your energy crashes every afternoon and you're relying on caffeine to keep going, the problem may not be a lack of energy at all. It may be a lack...
Why Some People Need Caffeine at 10 AM, 2 PM, a...
If your energy crashes every afternoon and you're relying on caffeine to keep going, the problem may not be a lack of energy at all. It may be a lack...
How Food, Family, and Science Come Together at ...
Healing begins at the table. NiHealth formulas are inspired by real, nutrient dense foods our ancestors used to support focus, recovery, circulation, immunity, and sleep. From brain supporting meals and...
How Food, Family, and Science Come Together at ...
Healing begins at the table. NiHealth formulas are inspired by real, nutrient dense foods our ancestors used to support focus, recovery, circulation, immunity, and sleep. From brain supporting meals and...
7 Myths and Facts about Melatonin.
By Dr. Billy Rutter, Founder, NiHealth Physician-formulated support, built from years of listening to patients. 7 Myths and The Facts About Melatonin Melatonin might be the most misunderstood supplement on...
7 Myths and Facts about Melatonin.
By Dr. Billy Rutter, Founder, NiHealth Physician-formulated support, built from years of listening to patients. 7 Myths and The Facts About Melatonin Melatonin might be the most misunderstood supplement on...
Extending the Conversation Beyond the Exam Room...
Discover why Dr. Billy Rutter created NiHealth to extend patient care beyond the exam room. Learn how nutrition, lifestyle science, and personalized health education can empower you to take control...
Extending the Conversation Beyond the Exam Room...
Discover why Dr. Billy Rutter created NiHealth to extend patient care beyond the exam room. Learn how nutrition, lifestyle science, and personalized health education can empower you to take control...
The Making of a Healer: Why I Became a Differen...
Optimize Healing Through Metabolic Support Healing cannot occur efficiently in the presence of metabolic dysfunction. Chronic inflammation, impaired microvascular circulation, oxidative stress, and nutrient deficiencies can significantly delay wound healing,...
The Making of a Healer: Why I Became a Differen...
Optimize Healing Through Metabolic Support Healing cannot occur efficiently in the presence of metabolic dysfunction. Chronic inflammation, impaired microvascular circulation, oxidative stress, and nutrient deficiencies can significantly delay wound healing,...